Kwimimandla ye-biopharmaceuticals kunye nophando lwesayensi, ukususwa kwe-solvent kunye nokugxila kwezinto ngamanyathelo abalulekileyo kwiinkqubo zovavanyo kunye nemveliso. Iindlela zemveli ezifana nokuphuma komphunga kunye ne-centrifugation zihlala zinengxaki yokungasebenzi kakuhle, ukulahleka kwezithako ezisebenzayo, kunye nokususwa kwe-solvent engaphelelanga. Ii-dryer dryers zelabhoratri, ezineenzuzo zazo ezikhethekileyo zobushushu obuphantsi kunye noxinzelelo oluphantsi, ziye zavela njengezixhobo ezisebenzayo kakhulu kwezi nkqubo. Phakathi kwazo,"ZOMBINI" ii-freezer dryersziphambili ekuphuculeni obu buchwepheshe.
Isayensi Ebangela Ukomisa Ngokukhenkceza: Ukuphelelwa ngamanzi emzimbeni ngamaqondo obushushu aphantsi
A isomisi sokukhenkceza elebhuifezekisa ukususwa kwe-solvent kunye nokugxila kwezinto ngokusebenzisa amanqanaba amathathu aphambili:
Inqanaba lokuqandisa ngaphambi kokubanda:Izinto eziqulethe izinyibilikisi ziqandiswa ngokukhawuleza kumaqondo obushushu aqala kwi -40°C ukuya kwi -80°C, zenze iikristale zomkhenkce eziqinileyo.
Ukomisa okuPhambili (Ukususwa kwenkunkuma):Phantsi kwendawo ene-vacuum (ngesiqhelo ingaphantsi kwe-10Pa), iikristale zomkhenkce ziyanyibilika ngqo kumphunga wamanzi, zisusa ngaphezulu kwe-90% yesinyibilikisi.
Ukomisa okwesibini (Ukufunxa):Ukunyuka kobushushu obuphantsi (20-40°C) kwenza kube lula ukufunxwa ngokupheleleyo kwamanzi adibeneyo, nto leyo ekhokelela kumthamo wokugqibela wokufuma we-1%-5%.
Le nkqubo isusa umonakalo obangelwa kubushushu obuphezulu kwizinto ezibuthathaka kubushushu, igcina ulwakhiwo lweemolekyuli zeeproteni, ii-enzymes kunye neevithamini. Ukongeza, idala ulwakhiwo olunemingxuma oluvumela ukubuyiselwa kwamanzi emzimbeni ngokulula okanye ukusetyenziswa ngokuthe ngqo.
Iingenelo eziphambili zeeLaboratory Freeze Dryers
Xa kuthelekiswa nezixhobo ezisetyenziswa kwimizi-mveliso, ii-laboratory freezer dryers zibonelela ngolawulo oluphezulu lokuchaneka kunye neenzuzo zokucubungula ezincinci:
Ulawulo lobushushu oluchanekileyo:Imodeli yomomisi womkhenkce "ZOMBINI"I-ZLGJ-12Umzekelo, isebenzisa iteknoloji yokupholisa yecompressor engeniswe kwamanye amazwe, ifikelela kumaqondo obushushu aphantsi njenge-80°C ukuqinisekisa ukuba ibanda ngokukhawuleza.
Ulawulo lwe-Vacuum olukrelekrele:Izinzwa ezichanekileyo kakhulu zihlala zijonga amanqanaba e-vacuum (≤5Pa), kunye neendlela zokukhusela ezakhelwe ngaphakathi ukuthintela ukugcinwa kwesinyibilikisi.
Ukufudumeza iGradient yoXinzelelo:Ixhotyiswe ngeshelufu yokufudumeza ecwangcisiweyo (njengeteknoloji yokulawula i-PLD "YOMBINI"), ezi nkqubo zivumela ii-curves zobushushu ezilungiselelwe izixhobo ezahlukeneyo, ziphucula uxinaniso.
Umzekelo, kuvavanyo lwebhayoloji olubandakanya ukomisa ii-antibody ngokuqandisa, iindlela zemveli zokufudumeza zikhokelele ekuhlanganisweni kweeproteni kunye nokuvala ukusebenza kwazo. Ngokwahlukileyo koko, ukomisa ii-antibody kumaqondo obushushu aphantsi kugcine ngaphezulu kwe-95% yomsebenzi wee-antibody, kunye nomgubo ophumayo uzinzile ngakumbi ukuze ugcinwe ixesha elide.
Njengenkampani egxile kwizixhobo zokomisa ikhenkcezisi zasekhaya kangangeminyaka eli-17, ii-"ZOMBINI" zokomisa ikhenkcezisi ziphucule ukusebenza kakuhle kokususa i-solvent ngokusebenzisa ubuchule obuqhubekayo bobuchwepheshe.
1. Inkqubo yokuLandelela idatha epheleleyo
Isixhobo sokomisa i-"BOBINI" selabhoratri esifakwe i-touchscreen yombala kunye nemodyuli yokugcina idatha (ekwaziyo ukugcina iirekhodi ezifikelela kwi-100,000). Sibonelela ngee-curves zobushushu-ze-vacuum zexesha langempela, senza abaphandi bakwazi ukumisela ngokuchanekileyo isiphelo se-solvent sublimation, ukuthintela ukoma kakhulu okanye iingxaki ze-solvent ezisele.
2. Iindlela ezininzi zoKhuseleko loKhuseleko
Ukutshixa kwepompo ye-vacuum cleaner ngokuzenzekelayo ukuba ubushushu betrap bungaphezulu kwe-50°C ukuthintela umonakalo wokubuyela umva.
Izandi kunye nezikhanyiso ezisebenza ngokhuseleko oluzenzekelayo xa kukho ukungasebenzi kakuhle kwe-vacuum okanye ubushushu obuguquguqukayo ngendlela engaqhelekanga.
Umbane we-UPS okhethwayo ugcina ukusebenza kwenkqubo yolawulo imizuzu engama-20 ngexesha lokucima kombane, ukuqinisekisa ukuqhubeka kovavanyo.
3. Ukwandiswa kweMisebenzi yeModular
Ngenkqubo yokufaka igesi ezenzekelayo yokuphinda icinezelwe, iigesi ezingasebenziyo ezifana ne-nitrogen zingangeniswa kwigumbi lokomisa ukuthintela ukusabela kwe-oxidation ngexesha lokuxinana kwezinyibilikisi ezibuthathaka kwioksijini (umz., i-ethanol). Igumbi, elenziwe ngentsimbi engatyiwayo ecocekileyo enoyilo lwetraphu engenazikhoyili, lisusa iingozi zokungcoliswa okunqamlezileyo.
Izixhobo zokomisa iifriji zelebhu ziye zavela kwizixhobo ezilula zokukhupha amanzi emzimbeni zaya kumaqonga okulawula iinkqubo antsonkothileyo.I-ZLGJuthotho, ngoyilo lwayo olukrelekrele nolunemodyuli, ayiphuculi nje kuphela ukusebenza kakuhle kokususa isinyibilikisi kodwa ikwavumela ukujonga nokuphucula inkqubo yokugxila ngexesha langempela. Kubaphandi ababeka phambili ukuchaneka kovavanyo kunye neziphumo ezizinzileyo, ezi zixhobo ziba "ngumncedisi wenkqubo esemgangathweni" oyimfuneko kwiilabhoratri.
Ixesha leposi: Matshi-13-2025
